| SAA Recordz | Germany | — | Original Production |
| Saboteur Records | France | May 17, 2018 | Production |
| Sacred Bones Records | — | — | — |
| Salad Days | — | — | Original Production |
| Sanctuary Records | — | — | — |
| Sanctuary Urban | United Kingdom | — | Original Production |
| Sanzuwu Group | — | 2024 | Original Production |
| SBTR Edition | — | May 17, 2018 | Publisher |
| Scapechoes Records | Brazil | 2024 | Original Production |
| Scred Productions | France | — | Production |
| Secteur 7 | France | — | — |
| Secunda Henderson Management | — | June 10, 2022 | Creative Agency |
| See No Equal Entertainment | — | May 11, 2012 | Original Production |
| Select Records | United States | 1981 | Original Production |
| Select Street Records | United States | — | Original Production |
| Selfmade Records | — | 2005 | Original Production |
| Selfmade Records | — | — | — |
| Serandip Records | — | April 27, 2020 | Original Production |
| Serenity Records | — | — | Original Production |
| Serjical Strike Records | — | — | — |
| Settle / @settlefm | Netherlands | — | Original Production |
| Seven Seas Entertainment | — | May 7, 1998 | Original Production |
| Sevensenza Production | France | 1997 | Production |
| Shade 45 | United States | — | Imprint |
| Shades Of Brooklyn Music | United States | — | Publisher |
| Shady Records | United States | 1999 | Original Production |
| Shady Records | — | — | — |
| Shadyville | United States | — | Production |
| Shootstar | France | — | Imprint |
| Shot Records | United States | — | Original Production |
| Shotta Glock Entertainment | — | October 14, 2021 | Imprint |
| Showoff Records | United States | 2003 | Original Production |
| Sichtexot | — | 2011 | Original Production |
| Sick Swan Records | Switzerland | — | Original Production |
| Sick Wid’ It Records | United States | — | Original Production |
| SIFTW Records & Arts | Sweden | August 30, 2011 | — |
| Silence Audible Productions | — | October 1, 2008 | Original Production |
| Silence d’Or | — | March 11, 2009 | Original Production |
| Six-O-Nine | France | November 2004 | Production |
| Sixieme Sens Produktion | France | — | Production |
| SK | United States | 2011 | — |
| Skenawin Éditions | France | September 16, 2022 | Publisher |
| Skyrock | — | March 21, 1986 | Broadcaster |
| Skyywalker Records | United States | March 27, 1990 | Original Production |
| SLAMjamz Records | — | 1996 | Original Production |
| Sleep Tales | Brazil | — | Original Production |
| Sleeping Kingz LLC | United States | 2010 | Publisher |
| Slice Rekordz | France | May 2, 1999 | Publisher |
| Slip‐N‐Slide Records | United States | 1994 | Original Production |
| Slowdown Records | — | — | Original Production |
| Smac Produções | Brazil | September 17, 2023 | Production |
| Smash Yo Records Charity Studio | United Kingdom | November 23, 2011 | Production |
| Smith & 9th | United States | 2017 | Original Production |
| Smoke On Records | Germany | 2009 | Production |
| SMPF Music | France | January 1, 2021 | Production |
| So So Def | United States | 1992 | Original Production |
| Socket Entertainment | Nigeria | January 16, 2023 | Original Production |
| Soft Tones Music | United States | — | Original Production |
| Solimusique | France | — | Production |
| Songstress Group | United States | August 2, 2018 | — |
| SOULY MUSIC | — | — | Production |
| Sound Effect Killer | France | — | Production |
| Sound Fi Dead Produktion | France | — | Production |
| Southern Comfort Entertainment LLC | — | January 25, 2000 | Original Production |
| Sparte Music | France | — | Production |
| SPEECHLIS Music / Daniel 7 Enterprises LTD | — | December 1, 2018 | Imprint |
| Spinefarm Records | — | — | — |
| SPITdigital Recordings | United States | — | Imprint |
| Splinter Collective | United States | April 1, 2023 | Original Production |
| SSO Artists Entertainment | — | January 8, 2019 | Distributor |
| Stamina Recordings | — | — | — |
| Star Trak | United States | 2002 | Original Production |
| Starizz | — | December 1, 2021 | Publisher |
| Starz Music | United States | — | Production |
| Station Zebra Recordz | France | — | Production |
| Stellar 90 | — | March 23, 2018 | Publisher |
| Stereofox Records | — | 2013 | Imprint |
| Steuerfreimoney | Germany | November 9, 2016 | — |
| Stigmate Prod. | France | — | Production |
| Stone Music Entertainment | South Korea | June 29, 1994 | Production |
| Stones Throw Records | United States | 1996 | Original Production |
| Str8 Shoota Entertainment | Canada | January 1, 2012 | Original Production |
| Streamtrack | — | January 1, 2021 | Original Production |
| Street Dance | — | — | Production |
| Strezless Musick | United States | — | Original Production |
| Strictly Rhythm | — | — | — |
| Studio 9:87 Recordings | Nigeria | January 2016 | Original Production |
| Style Mates Entertainment | — | October 6, 2015 | Imprint |
| Subconscious Communications | United States | 1993 | Original Production |
| Sublime | France | — | — |
| Subverzion Records | Belgium | April 7, 2008 | Publisher |
| Sugar Hill Records | — | — | — |
| Sugreev Roman Music | — | November 30, 2025 | Production |
| Sunday | — | — | Original Production |
| Suppe Inna Puppe | Germany | 2006 | Original Production |
| Supremos Records | — | January 1, 2016 | Publisher |
| Survival Sounds Music Group | United States | 2025 | Publisher |
| Suther Kane Films | France | November 9, 2004 | — |
| Sweme Squad Entertainment | — | November 1, 2016 | Production |
| Swishahouse | United States | 1997 | Original Production |