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- Slim JxmmiCity: InglewoodCountry: United States
- Slim ThugCity: HoustonCountry: United States
- SlimesitoCity: AtlantaCountry: United States
- Slimmie HendrixCountry: United StatesStarted in: 2000s
- SlimusCity: MoscowCountry: Russia
- SlinCrazeCountry: NorwayStarted in: 2000s
- SlugCity: MinneapolisCountry: United States
- Slut Boy BillyCity: ChiariCountry: Ghana
- Smigg DirteeCity: San DiegoCountry: United States
- SmileyCountry: CanadaStarted in: 2010s
- SminoCity: St. LouisCountry: United States
- SmokepurppCity: ChicagoCountry: United States
- SmolastyCity: WarsawCountry: Poland
- Snootie WildCity: MemphisCountry: United States
- SnowCity: North YorkCountry: Canada
- Snow Tha ProductCity: San JoseCountry: United States
- SobelCity: ŚwidnicaCountry: Poland
- Soda LuvCity: UkhtaCountry: Russia
- SoftboiledeggCountry: JapanGenres: hip-hop
- SogandCity: IsfahanCountry: Iran
- Soge CulebraCity: MurciaCountry: Spain
- SokółCity: WarsawCountry: Poland
- Solange KnowlesCity: HoustonCountry: United States
- SolarCity: SeoulCountry: South Korea
- SoleCity: PortlandCountry: United States
- Son of LightCountry: NorwayGenres: hip-hop
- Sonel FrancoisGenres: hip-hopBorn: August 22, 1989
- Song Min-hoCity: YonginCountry: South Korea
- Sonny RaveCountry: FranceGenres: hip-hop
- SoolkingCity: El HammametCountry: Algeria
- SopranoCity: MarseilleCountry: France
- Soul IDStarted in: 2000sGenres: hip-hop
- SoulJaCity: TokyoCountry: Japan
- Sound Da ClanStarted in: 1990sGenres: hip-hop
- SoundkailStarted in: 1990sGenres: hip-hop
- SoundzCity: DecaturCountry: United States
- South Park MexicanCity: HoustonCountry: United States
- Soyoka YoshidaCity: Osaka PrefectureCountry: Japan
- Space MarinesStarted in: 1990sGenres: hip-hop
- Spank RockCity: BaltimoreCountry: United States
- SpeakCity: BudapestCountry: Hungary
- Speaker KnockerzCity: ColumbiaCountry: United States
- SpectreCountry: United StatesStarted in: 1990s
- SpeechCity: MilwaukeeCountry: United States
- SpeedfreaksCity: NiteróiCountry: Brazil
- SpenzoStarted in: 2010sGenres: hip-hop
- Spider LocCity: ComptonCountry: United States
- SpinabenzCity: JacksonvilleCountry: United States
- Spoek MathamboCity: SowetoCountry: South Africa
- Spoonie GeeCity: HarlemCountry: United States
- SSPStarted in: 1990sGenres: hip-hop
- ST1MCity: TolyattiCountry: Russia
- StalleyCity: MassillonCountry: United States
- Staqk GCity: IbadanCountry: Nigeria
- Stat QuoCity: AtlantaCountry: United States
- Static MajorCity: LouisvilleCountry: United States
- StaySolidRockyCity: RichmondCountry: United States
- Steady BCity: PhiladelphiaCountry: United States
- Stefflon DonCity: BirminghamCountry: United Kingdom
- Stephen G. MelvilleCity: San AntonioCountry: United States
- Stereo MikeCity: PiraeusCountry: Greece
- Steven DanielCity: HartfordCountry: United States
- Steves J. BryanCity: Cap-HaïtienCountry: United States
- Stevie JCity: BuffaloCountry: United States
- Stiff BarbieCity: HoustonCountry: United States
- StigCity: HelsinkiCountry: Finland
- Stig BrennerCity: HamarCountry: Norway
- Stivo Simple BoyCountry: KenyaStarted in: 2010s
- Stomy BugsyCity: 9th arrondissement of ParisCountry: Cape Verde
- Stony BlydenCity: ReykjavíkCountry: Iceland
- StorCity: Huddinge MunicipalityCountry: Sweden
- StressCity: TallinnCountry: Estonia
- StretchCity: Springfield GardensCountry: United States
- StroCity: BrownsvilleCountry: United States
- StromaeCity: EtterbeekCountry: Belgium
- Strongman BurnerCountry: GhanaStarted in: 2010s
- StrukaCity: BelgradeCountry: Serbia
- Stunna 4 VegasCity: North CarolinaCountry: United States
- Stunna GambinoCity: Washington HeightsCountry: United States
- Stunna GirlCity: SacramentoCountry: United States
- Stylo GCity: Spanish TownCountry: United Kingdom
- Stéphane LegarCity: Bat YamCountry: Israel
- SubliminalCity: Tel AvivCountry: Israel
- SuboiCity: Ho Chi Minh CityCountry: Vietnam
- Subway SafariStarted in: 2000sGenres: hip-hop
- Suga FreeCity: PomonaCountry: United States
- Suga-TCountry: United StatesStarted in: 1980s
- Sugarhill DdotCity: HarlemCountry: United States
- SukihanaCity: WilmingtonCountry: United States
- SultanCity: Fontenay-aux-RosesCountry: France
- Summer CemCity: MönchengladbachCountry: Germany
- Sunny BoyCity: OshakatiCountry: Namibia
- Sunny MaltonGenres: hip-hopBorn: November 15, 1992
- Supa PeachCity: British Virgin IslandsCountry: United States
- SupastitionCity: CharlotteCountry: United States
- Super CatCity: KingstonCountry: Jamaica
- Super SakoCity: YerevanGenres: hip-hop
- Supreme BoiCountry: South KoreaStarted in: 2010s
- Sw@g BoyCity: SacramentoCountry: United States