| Salt-N-Pepa | Queens | United States | 1980s |
| Saïan Supa Crew | — | France | 1990s |
| SB19 | Manila | — | 2010s |
| Scred Connexion | — | France | 1990s |
| SDP | — | Germany | 2000s |
| Seventeen | Seoul | — | 2010s |
| Sexion d'Assaut | Paris | France | 2000s |
| SFDK | Seville | — | 1990s |
| Shanghai Restoration Project | New York City | — | 2000s |
| Shop Boyz | Bankhead | — | 2000s |
| Side Brok | Hovdebygda | — | 2000s |
| Sistars | — | — | 2000s |
| SKS Crew | — | France | 1990s |
| Slaughterhouse | Jersey City | — | 2000s |
| Slum Village | — | United States | 1990s |
| Slums Attack | — | — | 1990s |
| Smif-n-Wessun | New York City | United States | 1990s |
| Sniper | Paris | — | 1990s |
| SNJ | — | — | 1990s |
| Snook | Stockholm | — | 2000s |
| Snowgoons | — | Germany | 1990s |
| Soul II Soul | — | — | 1980s |
| Soul Militia | — | — | 1990s |
| Soul'd Out | — | — | 1990s |
| Souls of Mischief | Oakland | — | 1990s |
| Soulsonic Force | — | — | 1980s |
| Spooks | Philadelphia | — | 1990s |
| St. Lunatics | — | — | 1990s |
| Starflam | Liège | — | 1990s |
| Stavento | Alexandroupolis | — | 2000s |
| Stereo MCs | — | — | 1980s |
| Stereolizza | Kyiv | — | 2000s |
| Stetsasonic | New York City | — | 2000s |
| Stray Kids | — | — | 2010s |
| Strong Arm Steady | — | — | 2000s |
| Stupeflip | — | — | 2000s |
| Styles of Beyond | — | United States | 1990s |
| Subcarpați | — | — | 2010s |
| SudannaYuzuYully | — | — | 2010s |
| Sunday Service Choir | — | — | 2010s |
| Sunz of Man | New York City | — | 1990s |
| Suprême NTM | Saint-Denis | — | 1980s |
| Sweetbox | Los Angeles | — | 1990s |
| Swet Shop Boys | — | — | 2010s |